Release date: 2008-04-09 U.S. Development of H5N1 Virus Rapid Detection New Method The US Naval Health Research Center (NHRC) Respiratory Diseases Research Department said on March 27 that a preliminary study on the rapid antigen analysis test technology developed by Abo Microsystems (AVC) showed that The technology can effectively diagnose the bird flu virus in the human body.
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The detection method developed by Abo Microsystems uses the NS1 protein of the virus as a test object rather than a nuclear protein. Antigen capture is accomplished by a PDZ protein that is bundled in the C-terminal region of the NS1 protein. Since the C-terminal region of the NS1 protein differs for each influenza subtype, the researchers chose a PDZ protein that is highly correlated with the NS1 protein of the H5 strain as a pathway for assay.
The researchers said that the newly developed assay method is similar to the cross-flow rapid antigen assay. However, the role of the capture antibody in the new method is served by the PDZ protein, which has strong characteristics and binding ability. Cross-flow rapid detection has many advantages, such as ease of use, portability, speed and low price. ——Shanghai Medical Device Industry Association website