Russian scientists have developed a breakthrough in the field of medical diagnostics for stamp-size biochips

According to the Russian Pravda report on December 27, Russia has recently developed a stamp-sized biochip that can identify hundreds of pathogens and viruses, genetic mutations, and human resistance to certain types of cancer. The chip, together with its affiliated instruments, has obtained a national certificate from Russia, which is also known as a major breakthrough in the field of medical diagnostics because it can greatly increase the efficiency of medical diagnostics in the laboratory. Russian officials believe that the successful development of this chip has established the international image of Russia’s high-tech industry. The chip began development in the 1980s and was the result of 15 years of hard work by Russian scientists. It is internationally known as the "Russian biochip." His invention was closely linked with the late director of the Russian Academy of Molecular Biology Andrei Mirzabekov. Dr. Victor Baski, Ph.D. in the biological sciences department, said, “Over the years, many scientists believe that it is impossible to develop stamp-sized biochips. And Mizabekov believes that people can conquer the 'impossible'. He thinks that doing 'The thing is not interesting,'" the biochip's size and working ability are similar to those of an electronic chip. Scientists in the United Kingdom, Yugoslavia, and the former Soviet Union all have intentions for development. Yugoslav scholars were invited to the United States to carry out the study but they did not achieve any results. British scientists sold their intentions to a diagnostic instrument manufacturing company. The company decided to put the project on hold for a better time. In view of Russia's finding a shorter and more efficient and successful way, the United States proposed that Mizabekov should lead a biochip research center. He agreed, and he still retained the Russian research center. Russian experts started work in both laboratories in 2001. The biochip is a small square on a glossy metal plate. Only the size of the stamps, but can replace the entire laboratory, including its staff, hundreds of test tubes and dozens of different types of equipment. The operation of the biochip follows the principles of molecular biology. Dr. Alexander-Zashedat Treff said, “A robot drops a solution on a metal plate and detects changes in the molecules on it. These molecules are neither DNA fragments nor some type of protein, but bacteria, viruses, Toxins, etc. Then the metal plate is exposed to UV light, the dripping liquid is polymerized in microcells of similar nature, and a biochip can carry 4,000 microcells.” In the past, the lab could make 10 chips a day, ever since. Scientists work with robots, increasing their daily output to 70 and simplifying the process of pathogen identification. The researchers added fluorescent substances to the analyzed liquid (such as a drop of blood) and applied the liquid to the chip. The molecules in the liquid began to look for similar molecules on the chip to polymerize. Fluorescent substances make the virus and detectable genes flash. Therefore, it is easier to distinguish by microscope. Analyze images can also be enlarged and printed. Flashing cell images allow for a very complex analysis process that is simpler and less expensive. The Institute of Tuberculosis Research of the Russian Academy of Sciences has performed performance tests on this kind of chip. They found that in an ordinary laboratory, diagnosis may take two weeks to two months, and virologists can use biochips to complete in only a few hours, identifying pathogenic tissues that include certain dangerous diseases such as plague, cholera and smallpox. . The chip can also rapidly diagnose leukocytosis, thus providing doctors with more opportunities to save lives. The chip can also measure the quality of donated blood, detect genetic mutations of bird flu and fetuses that have attracted worldwide attention in recent years, identify identities, conduct various criminal analyses, and so on. Chip diagnosis is quicker and cheaper than many well-known and costly methods such as biochemical enzyme chain reaction diagnostics. The price of Russian chips is only 1/30 of that of foreign products. Academician Mizhabkov believes that continuous industrial production will make it cheaper. Russian biochips and their analytical devices are currently in use in laboratories in the United States, France, and North Korea.

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