Lab Supply Peptide Gdf-8 for Mass Gain GMP Certified Myostatin

Posted on

Model NO.: API
Appearence: Blue Powder
Color: White
Grade: Medicine Grade
Type: Vitamins, Amino Acids and Coenzyme
Application: Used
Packaging Details: 2mg/Vial 1mg/Vial
Trademark: Filter
Transport Package: Plastic Vial(Dedicated for Peptide Packing) or Gla
Specification: 2mg/vial
Origin: Shang Hai
HS Code: 2901291000
Model NO.: API
Appearence: Blue Powder
Color: White
Grade: Medicine Grade
Type: Vitamins, Amino Acids and Coenzyme
Application: Used
Packaging Details: 2mg/Vial 1mg/Vial
Trademark: Filter
Transport Package: Plastic Vial(Dedicated for Peptide Packing) or Gla
Specification: 2mg/vial
Origin: Shang Hai
HS Code: 2901291000
 
 
Supplier Homepage
Product Pharmaceutical Peptides Antibody Myostatin Gdf-8 for Adult with GMP (ODM)
Antibody Myostatin Gdf-8 for Adult with GMP (ODM)
US $15-30 / vials
FOB Price:
Min. Order: 10 vials
Min. Order FOB Price
10 vials US $15-30/ vials
Get Latest Price
Port: Shanghai, China
Production Capacity: 100kg
Payment Terms: L/C, T/T, D/P, Western Union, Paypal, Money Gram
Contact Now Request Sample
Chat with Supplier.Inquiry Basket Favorites

Request a custom order and have something just for you!

Send Customized Request
 
 
 
 
 
 
 
 
 
Basic Info
Model NO.: APICustomized: CustomizedSuitable for: AdultPurity: >98%Supply Ability: 1000 Kits Per MonthAppearance: White PowderName: Myostatin Gdf-8Transport Package: Plastic Tube, VialOrigin: ShanghaiPowder: YesCertification: GMPState: SolidCertificate: GMPStorage: Dry Cool PlacePacking: 10vials Per KitsTrademark: FILTERSpecification: 1mg/vialHS Code: 3003901000
Product Description
Product name:Myostatin GDF-8
Purity:85%
Specification:1mg/vial
Appearance:White powder
Certificate:GMP
Storage:Dry Cool Place
Grade:Medicine Grad

Product Description
Myostatin
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.

 Discovery and sequencing
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".
Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
 
Structure and mechanism of action
Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.


 
 
 

We are the direct factory which is located in zhengzhou, Henan province. We also specialize in  the research, development and production of kinds of Amino Acids,Pharmaceutical Polypeptide,Comestic Polypeptide,Vetenary Peptide and Pharmaceutical APIs. We provide good quality and best price with professinal technique.
 
1.COA HPLC MS be sent on request
2.A-Grade 
3.competitive price 
4.Fast delivery
 
 
 1)Delivery: Immediately by DHL/EMS/TNT within 10 days (If you have Forwarder in China,
 
the better.) 
 
 2)  Payment Terms: T/T or western union 
 
 
Please feel free to contact us if you have any other requirement, we accept custom-made.Most competitive price, best quality and best service will be provided.
 
 
  
 
T:008615294859659  
 
Supplier Homepage
Product Pharmaceutical Peptides Antibody Myostatin Gdf-8 for Adult with GMP (ODM)
Antibody Myostatin Gdf-8 for Adult with GMP (ODM)
US $15-30 / vials
FOB Price:
Min. Order: 10 vials
Min. Order FOB Price
10 vials US $15-30/ vials
Get Latest Price
Port: Shanghai, China
Production Capacity: 100kg
Payment Terms: L/C, T/T, D/P, Western Union, Paypal, Money Gram
Contact Now Request Sample
Chat with Supplier.Inquiry Basket Favorites

Request a custom order and have something just for you!

Send Customized Request
 
 
 
 
 
 
 
 
 
Basic Info
Model NO.: APICustomized: CustomizedSuitable for: AdultPurity: >98%Supply Ability: 1000 Kits Per MonthAppearance: White PowderName: Myostatin Gdf-8Transport Package: Plastic Tube, VialOrigin: ShanghaiPowder: YesCertification: GMPState: SolidCertificate: GMPStorage: Dry Cool PlacePacking: 10vials Per KitsTrademark: FILTERSpecification: 1mg/vialHS Code: 3003901000
Product Description
Product name:Myostatin GDF-8
Purity:85%
Specification:1mg/vial
Appearance:White powder
Certificate:GMP
Storage:Dry Cool Place
Grade:Medicine Grad

Product Description
Myostatin
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.

 Discovery and sequencing
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".
Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
 
Structure and mechanism of action
Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) amino acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.


 
 
 

We are the direct factory which is located in zhengzhou, Henan province. We also specialize in  the research, development and production of kinds of Amino Acids,Pharmaceutical Polypeptide,Comestic Polypeptide,Vetenary Peptide and Pharmaceutical APIs. We provide good quality and best price with professinal technique.
 
1.COA HPLC MS be sent on request
2.A-Grade 
3.competitive price 
4.Fast delivery
 
 
 1)Delivery: Immediately by DHL/EMS/TNT within 10 days (If you have Forwarder in China,
 
the better.) 
 
 2)  Payment Terms: T/T or western union 
 
 
Please feel free to contact us if you have any other requirement, we accept custom-made.Most competitive price, best quality and best service will be provided.
 
 
  
 
T:008615294859659