High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2

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Model NO.: Regorafenib Hydrate
Mf: C21h17clf4n4o4
MW: 500.83
CAS: 1019206-88-2
Trademark: DMK
Transport Package: Aluminum Foil Bag/Carton
Specification: API
Origin: China
HS Code: 29061310
Model NO.: Regorafenib Hydrate
Mf: C21h17clf4n4o4
MW: 500.83
CAS: 1019206-88-2
Trademark: DMK
Transport Package: Aluminum Foil Bag/Carton
Specification: API
Origin: China
HS Code: 29061310
High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2

Product name:Regorafenib hydrate
Other names:BAY 73-4506 monohydrate
CAS No.:1019206-88-2
Molecular formula:C21H17ClF4N4O4
Molecular weight:500.83
Storage :Store at -20°C
Solubility:Soluble in DMSO
Product Specifications:Pharmacopoeial grade
Description 
Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively.
High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2

Regorafenib Application:
Regorafenib strongly prevents VEGFR2 autophosphorylation in NIH-3T3/VEGFR2 cells with IC50 of 3 nM. In HAoSMCs, regorafenib suppress PDGFR-β autophosphorylation after stimulation with PDGF-BB, with an IC50 of 90 nM. Regorafenib also inhibits FGFR signaling in MCF-7 breast cancer (BC) cells stimulated with FGF10. Regorafenib very potently inhibited the mutant receptors KITK642E and RETC634W, with IC50 of approximately 20 nM and 10 nM, respectively. Regorafenib inhibits the proliferation of VEGF165-stimulated HUVECs, with an IC50 of approximately 3 nM. Regorafenib prevents the proliferation of FGF2-stimulated HUVECs and of PDGF-BB-stimulated HAoSMCs with IC50 of 127 nM and 146 nM, respectively. Regorafenib targets both tumor cell proliferation and tumor vasculature through inhibition of receptors of tyrosine kinases (VEGFR, KIT, RET, FGFR, and PDGFR) and serine/threonine kinases (Raf and p38MAPK). Regorafenib suppresses growth of human Hep3B, PLC/PRF/5 and HepG2 cells in a concentration- and time-dependent manner. 
Regorafenib reveals potent dose-dependent TGI in various preclinical human xenograft models in mice, with tumor shrinkages in breast MDA-MB-231 and renal 786-O carcinoma models. Regorafenib prevents not only the growth of syngeneic primary 4T1 breast tumors growing orthotopically in the fat pad, but also suppresses the formation of tumor metastasis in the lung. 
 
Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RETand TIE2.
Regorafenib is a multikinase inhibitor of both intracellular and membrane-bound RTKs. It shows potent inhibition of angiogenic and stromal RTKs like VEGF receptors-1-3, PDGFR-β and FGF receptor-1 with IC50 values ranging from4.2 to 311nM in biochemical assays. It also inhibits oncogenic RTKs, such as RET and c-KIT, with IC50 values ranging from 1.5 to 28nM in cellular assays.
 
Regrafenib is reported to have anti-tumor efficacy to various tumors including breast, pancreas, thyroid, melanoma, GIST, and CRC with a mean IC50 value less than 1μM. These inhibition effects of tumor growth are also found in mouse xenograft models after the treatment of regorafenib at dose ranging from 10 to 100 mg/kg.
High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2

High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2
MonoMethyl Dolastatin 10 203849-91-6
MMAE 474645-27-7
MMAF 745017-94-1
DM1 139504-50-0
Vandetanib 443913-73-3
nintedanib 656247-17-5
PF06463922 1454846-35-5
AZD6244/ Selumetinib 606143-52-6
INCB28060 606143-52-6
BKM120 944396-07-0 
AZD3759 1626387-80-1
AP26113 1197958-12-5
linifanib/ABT-869 796967-16-3
AZD9291 1421373-66-1
WZ4002 1213269-23-8
dacomitinib 1110813-31-4
crizotinib  877399-52-5
Regorafenib hydrate 1019206-88-2
regorafenib  755037-03-7
Imatinib Mesylate 220127-57-1
Argireline Acetate 616204-22-9
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
3. How to cooperate with us?
You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email. 

Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept T/T  , Moneygram , Western Union.

Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8  How to proceed order?
Let me konw the items,quantity and the destination contury wihch help me to give you a right price
Please let me know the items you are looking for, quantity and the destination country.After you confirm all details of order, pay money 100% in advance and give us Shipping address.We arrange the shipment at first time after receive payment and offer after-sales service after you receive parcel.
High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2
High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2

High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2
  High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2

Product name:Regorafenib hydrate
Other names:BAY 73-4506 monohydrate
CAS No.:1019206-88-2
Molecular formula:C21H17ClF4N4O4
Molecular weight:500.83
Storage :Store at -20°C
Solubility:Soluble in DMSO
Product Specifications:Pharmacopoeial grade
Description 
Regorafenib (BAY 73-4506) is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1 with IC50 of 13 nM/4.2 nM/46 nM, 22 nM, 7 nM, 1.5 nM and 2.5 nM in cell-free assays, respectively.
High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2

Regorafenib Application:
Regorafenib strongly prevents VEGFR2 autophosphorylation in NIH-3T3/VEGFR2 cells with IC50 of 3 nM. In HAoSMCs, regorafenib suppress PDGFR-β autophosphorylation after stimulation with PDGF-BB, with an IC50 of 90 nM. Regorafenib also inhibits FGFR signaling in MCF-7 breast cancer (BC) cells stimulated with FGF10. Regorafenib very potently inhibited the mutant receptors KITK642E and RETC634W, with IC50 of approximately 20 nM and 10 nM, respectively. Regorafenib inhibits the proliferation of VEGF165-stimulated HUVECs, with an IC50 of approximately 3 nM. Regorafenib prevents the proliferation of FGF2-stimulated HUVECs and of PDGF-BB-stimulated HAoSMCs with IC50 of 127 nM and 146 nM, respectively. Regorafenib targets both tumor cell proliferation and tumor vasculature through inhibition of receptors of tyrosine kinases (VEGFR, KIT, RET, FGFR, and PDGFR) and serine/threonine kinases (Raf and p38MAPK). Regorafenib suppresses growth of human Hep3B, PLC/PRF/5 and HepG2 cells in a concentration- and time-dependent manner. 
Regorafenib reveals potent dose-dependent TGI in various preclinical human xenograft models in mice, with tumor shrinkages in breast MDA-MB-231 and renal 786-O carcinoma models. Regorafenib prevents not only the growth of syngeneic primary 4T1 breast tumors growing orthotopically in the fat pad, but also suppresses the formation of tumor metastasis in the lung. 
 
Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RETand TIE2.
Regorafenib is a multikinase inhibitor of both intracellular and membrane-bound RTKs. It shows potent inhibition of angiogenic and stromal RTKs like VEGF receptors-1-3, PDGFR-β and FGF receptor-1 with IC50 values ranging from4.2 to 311nM in biochemical assays. It also inhibits oncogenic RTKs, such as RET and c-KIT, with IC50 values ranging from 1.5 to 28nM in cellular assays.
 
Regrafenib is reported to have anti-tumor efficacy to various tumors including breast, pancreas, thyroid, melanoma, GIST, and CRC with a mean IC50 value less than 1μM. These inhibition effects of tumor growth are also found in mouse xenograft models after the treatment of regorafenib at dose ranging from 10 to 100 mg/kg.
High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2

High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2
MonoMethyl Dolastatin 10 203849-91-6
MMAE 474645-27-7
MMAF 745017-94-1
DM1 139504-50-0
Vandetanib 443913-73-3
nintedanib 656247-17-5
PF06463922 1454846-35-5
AZD6244/ Selumetinib 606143-52-6
INCB28060 606143-52-6
BKM120 944396-07-0 
AZD3759 1626387-80-1
AP26113 1197958-12-5
linifanib/ABT-869 796967-16-3
AZD9291 1421373-66-1
WZ4002 1213269-23-8
dacomitinib 1110813-31-4
crizotinib  877399-52-5
Regorafenib hydrate 1019206-88-2
regorafenib  755037-03-7
Imatinib Mesylate 220127-57-1
Argireline Acetate 616204-22-9
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us. 
 
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC , 
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
3. How to cooperate with us?
You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email. 

Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price. 

Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we'd like to accept T/T  , Moneygram , Western Union.

Q6:How long does it take to the goods arrived ?
A:It is Depending on your location,
    For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q7  Do  you  have  any  reshipment  policy ?  
we have good after-sale service and re-shipment policy if the parcel  lose
Our long association with  our clients has brought great benefits
We always take the upmost care in the packaging of our products 
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship
 
Q8  How to proceed order?
Let me konw the items,quantity and the destination contury wihch help me to give you a right price
Please let me know the items you are looking for, quantity and the destination country.After you confirm all details of order, pay money 100% in advance and give us Shipping address.We arrange the shipment at first time after receive payment and offer after-sales service after you receive parcel.
High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2
High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2

High Purity Above 99% Regorafenib Hydrate Vegfr2 Inhibitors CAS: 1019206-88-2
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