((17α , 20E) -17, 20-[ (1-methoxyethylidene) Bis- (oxy) ]-3-Oxo-19-Norpregna-4, 20-Diene-21-Carbo Sarms Yk11

Posted on

Model NO.: YK11
Classification: Sarms
Assay: 99%
Trademark: zhaoke
Transport Package: Aluminum Foil Bag
Specification: USP
Origin: China
Model NO.: YK11
Classification: Sarms
Assay: 99%
Trademark: zhaoke
Transport Package: Aluminum Foil Bag
Specification: USP
Origin: China
What is YK11?
(17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), which the myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor (AR) partial agonist. 
YK11 is a selective androgen receptor modulator (SARM), which activates AR without the N/C interaction. In this study, we further investigated the mechanism by which YK11 induces myogenic differentiation of C2C12 cells. The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody.
Myogenic differentiation is in reference to the products ability to block myostatin. Myostatin inhibition has been a really popular movement since the ban of most prohormones as it looks to be a relatively unexplored area for muscle growth and fat loss. There are currently a lot of claims about mystatin inhibition, but not so much factual data on these products. YK11 will have similar affects to DHT (possibly more potent) without the negatives of DHT. What this means is that the product will most likely be suppressive and require a post cycle, but not cycle support. It also won't have androgenic side affects like hair loss, acne, etc. The increase in follistatin caused by YK11 will act as an antagonist to mystatin (it will block myostatin) as well as the anabolic growth properties of YK11.
How it works?
Animal Research:
In direct comparison to to LGD-4033 as the reference for assay upon animal models of anabolism and androgenicity, YK-11 demonstrated higher efficacy withing anabolic parameters and lesser androgenicity at equivalent dosages.
It induces muscle cells to make more follistatin which is a strong myostatin inhibitor. Myostatin (also known as growth differentiation factor 8, is a myokine (protein) produced by muscle cells that acts on muscle cells to inhibit myogenesis. Myogenesis is muscle cell growth and differentiation. Research through the years show that when you block myostatin, it allows for significantly more muscle mass. So in research myostatin inhibitors are researched to find cures for muscle diseases.
We expect YK11 to be more potent than SARM LGD in terms of overall growth and feel. At this time, we expect this to be the strongest SARM on the market at a regular dosing. While suppression can occur, we expect this product to have low androgenic properties and can be used by both men and women. From our experience with SARMs, we find there are less losses of on-cycle results than pro-hormones, although typically not as potent. We do expect this product to have similar results as a moderately dosed Halodrol, without the alpha-male/androgenic feelings while on it.
Dosages and Suggestion
Recommended maximum dose YK11 is require dosages of 2.0-5.0mg b.i.d. in males and 0.5mg-2mg b.i.d. in females to achieve optimal effects in humans for the noted indications.

We are supplying:

Tam*oxif*en citrate/No*lvad*ex
CAS: 54965-24-1
 
Raws Name(hot sell) Abbr
Test* Base TB
Test* Enan  TE
Test* Cyp  TC
Test* Iso  TI
Test* Deca  TD
Test* Unde  TU
Test* Prop  TP
Test* Phenylp  TPP
Test* ace  TA
Sus250 (Test mixed) s250
4-Chlorotest ace  /
4-Chlorodehydromethylt  /
   
Bold  B
Bold ace  BA
Bold* Unde*  EQ BU
Bold Cyp  BC
   
Nand  N
Na*nd*  De*ca  ND
Nand  Cy  NC
Nand  Unde   NU
Nand*  Phenylp  N*P*P
   
Oxan /Anav  OA
Oxyme  /Anadr  Oxy
Stano /Winstr ST
Metand /Danab DB
Tr*en* ace (Revalor-H) TBA
Tr*en* Enan  TBE
Methe ace*tate  MA
Methe enan*thate ME
Dros*tano*l Enan DE
Drosta*nolo* Prop*ionate(Maste) DP
                                  and so on …  
   
Peptides Name Spec
GHR*-6 5mg
GHR*-2 5mg 
Ipamor*lin  2mg 5mg
M*lanotan I 10mg 
M*-II 10mg
CJ*-1295 (DAC) 2mg 
CJ*-1295 (without DAC) 2mg 
MG* (IG*-1 EC) 2mg
P*-141 10mg
S*rmorelin  2mg 
P*G-MGF  2mg 
DS*IP 2mg 5mg
sel*ank  2mg
Oxyt*ocin 2mg 
Gonado*relin  2mg 
Tripto*relin  100ug
GH*RH  2mg 
Tesa*morelin  2mg
Fra*g(176-191) 2mg 5mg 
Hexareli*n 2mg 5mg 10mg
Thymos*in Beta 4 (TB4) Model: TB-500 2mg 5mg 10mg
H*H blue/red/green/yellow to*ps    10iu
Hy*getropin/Jin*tropin/Kig*tropin/Rip*tropin  10iu 
H*C*G 5000iu 
   
Sarms  
MK2866 841205-47-8
SR9009 1379686-30-2
RAD140 1182367-47-0
MK677 15972-10-0
S4 401900-40-1
YK11 431579-34-9
LGD-4033 1165910-22-4
GW-501516 317318-70-0



((17α , 20E) -17, 20-[ (1-methoxyethylidene) Bis- (oxy) ]-3-Oxo-19-Norpregna-4, 20-Diene-21-Carbo Sarms Yk11


* Safe and fast delivery

* Special and concealed package

* Competitive and reasonable price

Please feel free to contact us and we will do our best to help you. Thank you.



 

Hubei Zhaoke Bio-Chemical Co., Ltd.
  What is YK11?
(17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), which the myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor (AR) partial agonist. 
YK11 is a selective androgen receptor modulator (SARM), which activates AR without the N/C interaction. In this study, we further investigated the mechanism by which YK11 induces myogenic differentiation of C2C12 cells. The induction of key myogenic regulatory factors (MRFs), such as myogenic differentiation factor (MyoD), myogenic factor 5 (Myf5) and myogenin, was more significant in the presence of YK11 than in the presence of DHT. YK11 treatment of C2C12 cells, but not DHT, induced the expression of follistatin (Fst), and the YK11-mediated myogenic differentiation was reversed by anti-Fst antibody.
Myogenic differentiation is in reference to the products ability to block myostatin. Myostatin inhibition has been a really popular movement since the ban of most prohormones as it looks to be a relatively unexplored area for muscle growth and fat loss. There are currently a lot of claims about mystatin inhibition, but not so much factual data on these products. YK11 will have similar affects to DHT (possibly more potent) without the negatives of DHT. What this means is that the product will most likely be suppressive and require a post cycle, but not cycle support. It also won't have androgenic side affects like hair loss, acne, etc. The increase in follistatin caused by YK11 will act as an antagonist to mystatin (it will block myostatin) as well as the anabolic growth properties of YK11.
How it works?
Animal Research:
In direct comparison to to LGD-4033 as the reference for assay upon animal models of anabolism and androgenicity, YK-11 demonstrated higher efficacy withing anabolic parameters and lesser androgenicity at equivalent dosages.
It induces muscle cells to make more follistatin which is a strong myostatin inhibitor. Myostatin (also known as growth differentiation factor 8, is a myokine (protein) produced by muscle cells that acts on muscle cells to inhibit myogenesis. Myogenesis is muscle cell growth and differentiation. Research through the years show that when you block myostatin, it allows for significantly more muscle mass. So in research myostatin inhibitors are researched to find cures for muscle diseases.
We expect YK11 to be more potent than SARM LGD in terms of overall growth and feel. At this time, we expect this to be the strongest SARM on the market at a regular dosing. While suppression can occur, we expect this product to have low androgenic properties and can be used by both men and women. From our experience with SARMs, we find there are less losses of on-cycle results than pro-hormones, although typically not as potent. We do expect this product to have similar results as a moderately dosed Halodrol, without the alpha-male/androgenic feelings while on it.
Dosages and Suggestion
Recommended maximum dose YK11 is require dosages of 2.0-5.0mg b.i.d. in males and 0.5mg-2mg b.i.d. in females to achieve optimal effects in humans for the noted indications.

We are supplying:

Tam*oxif*en citrate/No*lvad*ex
CAS: 54965-24-1
 
Raws Name(hot sell) Abbr
Test* Base TB
Test* Enan  TE
Test* Cyp  TC
Test* Iso  TI
Test* Deca  TD
Test* Unde  TU
Test* Prop  TP
Test* Phenylp  TPP
Test* ace  TA
Sus250 (Test mixed) s250
4-Chlorotest ace  /
4-Chlorodehydromethylt  /
   
Bold  B
Bold ace  BA
Bold* Unde*  EQ BU
Bold Cyp  BC
   
Nand  N
Na*nd*  De*ca  ND
Nand  Cy  NC
Nand  Unde   NU
Nand*  Phenylp  N*P*P
   
Oxan /Anav  OA
Oxyme  /Anadr  Oxy
Stano /Winstr ST
Metand /Danab DB
Tr*en* ace (Revalor-H) TBA
Tr*en* Enan  TBE
Methe ace*tate  MA
Methe enan*thate ME
Dros*tano*l Enan DE
Drosta*nolo* Prop*ionate(Maste) DP
                                  and so on …  
   
Peptides Name Spec
GHR*-6 5mg
GHR*-2 5mg 
Ipamor*lin  2mg 5mg
M*lanotan I 10mg 
M*-II 10mg
CJ*-1295 (DAC) 2mg 
CJ*-1295 (without DAC) 2mg 
MG* (IG*-1 EC) 2mg
P*-141 10mg
S*rmorelin  2mg 
P*G-MGF  2mg 
DS*IP 2mg 5mg
sel*ank  2mg
Oxyt*ocin 2mg 
Gonado*relin  2mg 
Tripto*relin  100ug
GH*RH  2mg 
Tesa*morelin  2mg
Fra*g(176-191) 2mg 5mg 
Hexareli*n 2mg 5mg 10mg
Thymos*in Beta 4 (TB4) Model: TB-500 2mg 5mg 10mg
H*H blue/red/green/yellow to*ps    10iu
Hy*getropin/Jin*tropin/Kig*tropin/Rip*tropin  10iu 
H*C*G 5000iu 
   
Sarms  
MK2866 841205-47-8
SR9009 1379686-30-2
RAD140 1182367-47-0
MK677 15972-10-0
S4 401900-40-1
YK11 431579-34-9
LGD-4033 1165910-22-4
GW-501516 317318-70-0



((17α , 20E) -17, 20-[ (1-methoxyethylidene) Bis- (oxy) ]-3-Oxo-19-Norpregna-4, 20-Diene-21-Carbo Sarms Yk11


* Safe and fast delivery

* Special and concealed package

* Competitive and reasonable price

Please feel free to contact us and we will do our best to help you. Thank you.



 

Hubei Zhaoke Bio-Chemical Co., Ltd.
 

Medicine

Rauwolfia Tablets ,Primidone Tablets ,Trepibutone Tablets

Medicine,Health Food Co., Ltd. , http://www.cn-medicines.com