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Base and Socket Base and Socket, Base For UV Lamp, UV Germicidal Lamp Ningbo Sunfine UV lighting Co.,ltd. , http://www.uvlightings.com
Base and Socket
New Breeding Cloning Pigs in the UK
The British company PPL Medical, which once participated in the cloning of Dora Dolly, announced on the 2nd that researchers at the company had recently cultivated five new transgenic clone pigs with a gene "closed" in their bodies. This is another important advance in the field of xenotransplantation research. According to a press release issued by the PPL company, the five piglets were bred by researchers of the company's subsidiary in Virginia, USA. Both were female and were born on December 25, 2001. DNA tests showed that one of the two "alpha" 1 (3 galactosyltransferase) (GT) genes in their bodies is in a "closed" state. The researchers said that the GT gene controls the production of an enzyme that produces a carbohydrate on the surface of pig cells. When a porcine organ or cell is transplanted into the human body, the human immune system can recognize this sugar, thereby generating a strong rejection reaction and treating the transplanted organ or cell as foreign foreign matter. This is the main reason why pig organs cannot be applied to human transplants. By finding ways to suppress this gene, it is possible to use genetically modified cloned pigs to "produce" organs that are suitable for transplant surgery. PPL has cooperated with the Rothlin Institute in the United Kingdom to develop cloned sheep Dolly using nuclear transfer technology. Since then, the company is committed to using the same technology to breed transgenic cloned pigs that are suitable for transplant surgery. In March 2000, PPL announced that it had produced the world's first batch of cloned pigs. In April 2001, it announced that it had cloned the first batch of transgenic pigs containing exogenous genes in vivo. This successful breeding of cloned pigs with a "closed" GT gene indicates that the goal of practical application of xenotransplantation has become closer and closer. Due to the lack of organs for transplantation, many patients who urgently need kidney replacement, liver or heart are not being treated promptly. Research on xenotransplantation transplanting animal organs to humans has therefore received attention. Pigs are prone to reproduction, and their organs are closer in size and function to human organs, and are thus considered to be ideal sources of alternative organs. Scientists at PPL expect that the first medical application of transgenic cloned pigs will be to manufacture insulin-producing islet cells for the treatment of diabetes, and the relevant clinical trials may begin as early as four years.