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Bisphenol A (BPA) is commonly used in industrial production, especially in the production of resins and plastics as food and beverage packaging materials; it has been the subject of numerous studies and, in some cases, has certain human health issues. Contact. A study estimates that detectable levels of BPA are present in more than 90% of the US population. In response to this news, the American Medical Association (Ame rican Me dic al Association) called for more research, and the European Food Safety Authority has begun to assess human health risks; in 2008, Canada announced that BPA is a harmful substance. In response to this growing concern, ASTM International recently published Method D7574-09 – “Standard Test for the Determination of Bisphenol A in Environmental Water by Liquid Chromatography/Tandem Mass Spectrometry†(Standard Test) Method for Determination of Bisphenol Ain Environmental Waters by Liquid Chromatography / Tandem MassSpectrometry). This method was developed and validated by the US Environmental Protection Agency (US EPA) using Waters' environmental solutions. 
ASTM METHOD D7575-09
The published ASTM Method D7475-09 uses a combination of solid phase extraction and liquid chromatography/mass spectrometry/mass spectrometry to analyze BPA in water. A number of measures have been taken to prevent sample contamination and to develop to higher concentrations. One of the measures is the use of a glass SPE cartridge designed specifically for low levels of detection of BPA and other estrogenic compounds in river water. Since the concentration of BPA in the liquid chromatography system (LC) is extremely low (actually below the meaningful detection limit [MDL]), a separation column is used as an additional separation measure.
â– For the detection of surface water and POTW wastewater samples, the MDL of this method is 5ng/L
â– For more information on this method, please visit:
Multi-residue endocrine disruptor method
In addition to supporting the efforts of US EPA and ASTM to develop BPA analytical methods, Waters scientists have developed their own multi-residue method for this compound and its related target substances. As part of this process, Waters introduced a method for determining endocrine disrupting compounds in river water using ACQUITY UPLC tandem quadrupole mass spectrometry. The instrumentation and SPE steps used in this method are the same as the ASTM method except that the LC condition settings are slightly modified to accommodate a wider range of analytes.
While maintaining sensitivity and resolution, the UPLC® method was optimized to reduce total run time and six endocrine disrupting compounds (including BPA) were successfully detected in actual surface water samples.
The total run time was reduced to 8 minutes and the 1 mg/mL standard was injected 20 μL. Quattro PremierTM XE achieved good sensitivity in negative ion mode: 
The Waters ACQUITY UPLC Bisphenol A kit helps researchers successfully perform BPA analysis in accordance with ASTM Method D7574-09. The products listed in the kit are the same as those used by government researchers and have been validated in conjunction with this method. For scientists who are keen to modify the ASTM method, these products in the kit are also suitable for their modification work, as the Waters scientists have confirmed. Featuring state-of-the-art technology from ACQUITY UPLC and optimized sample purification from Oasis® SPE glass cartridges, this kit offers the same level of performance and sensitivity as ASTM methods. 
Bisphenol A bottle was banned - analysis of bisphenol A in water using ACQUITY UPLC technology
Bisphenol A bottle was banned
Waters Technology (Shanghai) Co., Ltd. (Waters)
The milk powder has not been in trouble, and the bottle crisis has arrived. Recent studies have shown that bisphenol A has certain uncertainties or side effects, or is harmful to development, endocrine, and the like. The European Commission has decided to ban the use of plastics containing chemical substances bisphenol A to produce baby bottles; countries such as the United States and Canada have also stopped using plastic bottles containing bisphenol A for babies. From June 1st, China has banned the production of infant and baby bottles containing bisphenol A. It is banned from importing and selling since September 1. The so-called bisphenol A, referred to as bisphenol propane (BPA), is an important raw material for PC plastics. Because it has excellent electrical insulation, elongation, dimensional stability and chemical resistance, it can be said that BPA is ubiquitous. How to accurately detect the bisphenol A content in the sample becomes our common The topic of concern. For the detection of bisphenol A, we have a complete solution.
ACQUITY UPLC BisPhenoL A Kit Analyzes Bisphenol A in Water Using ACQUITY UPLC Technology
The SPE extraction method was verified by 5 parts of 200 mL river water at two different concentration levels (10 ng/L and 100 ng/L). Six target analytes showed good recovery and reproducibility: average recovery and %RSD of estrogen and bisphenol A in river water at 10 ng/L and 100 ng/L added levels
Quattro Premier XE is sensitive and selective for 50 ng/mL estrogen and bisphenol A in river water matrix. The detection limit (LOD) of the method was calculated by calculation, indicating that it is sufficient to monitor the actual surface water sample. If necessary, these values ​​can also be optimized by increasing the volume of water extracted:
Selection of bisphenol A method