Ibrutinib is a small molecule drug that binds permanently to a protein, Bruton's tyrosine kinase (BTK) that is important in B cells; the drug is used to treat B cell cancers like mantle cell lymphoma, chronic lymphocytic leukemia, and Waldenstrom's macroglobulinemia, a form of non-Hodgkin's lymphoma.
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1, hatchlings wintering
The newly hatched turtle is called a hatchling. After hatching from turtle eggs, juvenile tortoises have fragile physique and poor adaptability to the external environment. They consume more energy during the long winter, such as improper management and high winter mortality. From the beginning of the frost, the hatchlings stopped feeding. After larch (at the end of October) for 1 week, hatchlings should be transferred from outdoor to indoor pool for winter. The indoor pool should be filled with sand in advance and the sand should be rinsed with clean water or tap water. After the hatchlings have infiltrated into the sediment, a net cover is required on the pool to prevent enemy invasion. Sediment should maintain a certain humidity, and it is necessary to squeeze into a group but not to accumulate water. When the silt is too dry, it should be sprinkled with water. The temperature difference of the water should not exceed 2°C. The temperature of the indoor wintering pool must be kept above 0°C to prevent freezing of the pool water. The juvenile turtle organisms will die when they reach the freezing point. When the temperature is too low. Pads can be covered in straw. The hatchlings do not feed when they are wintering, and generally have a density of 100 to 150 per square meter. Young hatchlings are small and delicate. Before the snowfall (late January), regardless of whether the water temperature meets the theoretical requirements, the hatchlings must end their wintering work.
2, young turtles winter
After hatching, the juvenile is younger than 2 years of age, and the gonad is not mature. Young turtles are also not resistant to low temperatures. If you stay in the outdoor natural pond for winter, the density should not be too large, 20-30 per square meter. The water depth is more than 1 meter. Put 10 to 20 centimeters thick silt at the bottom of the pool, take a cold rack on the pool, put a plastic film on the rack, leave l-2 ventilation tubes, and cover the straw curtain on the film for winter. If the cement is overwintering in winter, the overwintering method is the same as that of hatchlings. Since 1978, the author has used more than 5,000 baby turtles to winter in outdoor caves, which works well. Specific methods: In sheltered sunny areas, dig 50-60 cm deep earthen ponds, depending on the size of the number of young turtles to local conditions. Tongkou is set up with wooden sticks or planks for the purpose of preventing the permafrost, covered with straw mats, and piled with mud. Drain wells around. Leave 2-3 vent holes in the sunny area of ​​Tangkou, and you can make the baby turtles well-placed in winter.
3, turtles wintering
(1) In order to restore the balance of the turtle's body after spawning, increase the amount of feed with high protein and fat content before winter. Live animal feeds and compound feeds are released simultaneously. In the feed, appropriate amounts of lysine, methionine, and multi-dimensional additives are added to store a certain amount of nutrients in the overwintering protozoa. In order to achieve the purpose of disease-free early prevention, each 50 kg bait can be added with some red and blue flowers, chrysanthemum, licorice, Banlangen and other Chinese herbal medicine 20-30 grams of Jianzhi bait feeding.
(2) Overwintering pools should be chosen so that they can keep quiet and calm. At the bottom of the pool, 20 cm thick silt is required to allow the turtle to dive into the silt for wintering. In order to make turtles wake up after a good water environment, before winter, disinfection of the rearing pool water, use 100 to 200 grams of lime per square meter, 8 days after the change of water reserve.
(3) Before going through the winter, carefully select and inspect turtles. Requests the turtle to have normal body color and a strong physique. Hook fishing, fork catching, electric catching, surface injury, slow crawling turtles, should be put alone, can not enter the pool winter.
(4) Before the small snowfall after the frost, put 1/3 of the pool area in the rearing pond. The grass should not be too much, which will affect the light. The four corners of the rearing tank applied crop straws to take temporary wind walls to prevent sudden attacks from cold currents.
Ibrutinib is used to treat chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, and as a second-line treatment for mantle cell lymphoma, and marginal zone lymphoma.
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Turtle Overwintering Technology
Turtles are temperature-changing animals and require strict environmental temperature and high technical requirements. So the wintering of the turtle is a difficult time. Here are some of the practical experiences of turtle wintering: