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Developing a zebrafish model of cardiac drugs
In the September issue of Nature-Chemistry Biology, researchers reported for the first time a high-throughput analysis of tissue function in living vertebrates. The monitoring of tissue function in living organisms is a powerful tool for observing the effects of drugs in living organisms. However, the need to assess the effect of drugs on individual tissues still presents a challenge to automatic high-throughput identification of tissue function. C. Geoffrey Burns and colleagues developed an automated fluorescence microscopy assay that monitors zebrafish heart beat. They will use green fluorescent tags placed in the myocardium of zebrafish embryos. Using this transgenic zebrafish, they accurately measured the rate of heartbeat per minute. Burns and colleagues used this method to measure the response of the zebrafish's heart to drugs that affect heart rate, such as the response to the estrogen drug tamoxifen. The new method will be an important tool for the development of heart medicines. In addition, applying this method to the determination of other physiological parameters will open a new door for genre-based overall tissue scans.